Comparative Pathology of Neurovirulent Lineage 1 (NY99/385) and Lineage 2 (SPU93/01) West Nile Virus Infections in BALBc Mice
نویسندگان
چکیده
منابع مشابه
Pathology of fatal lineage 1 and 2 West Nile virus infections in horses in South Africa.
Since 2007, West Nile virus (WNV) has been reported in South African horses, causing severe neurological signs. All cases were of lineage 2, except for one case that clustered with lineage 1 viruses. In the present study, gross and microscopic lesions of six South African lineage 2-infected horses and the one lineage 1 case are described. Diagnoses were confirmed by real-time reverse-transcript...
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Lineage 2 West Nile virus (WNV) strains are endemic in South Africa and cause severe neurological disease in horses. An inactivated lineage 1 vaccine, Duvaxyn WNV, protects mice against challenge with a neuroinvasive South African lineage 2 strain of WNV. To evaluate the potential of Duvaxyn WNV to protect horses against lineage 2 strains of WNV, serum neutralising antibody responses of horses ...
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The low diversity we found could be explained by a recent introduction of the bacteria into the area [although A. phagocytophilum–seropositive horses have been found in the area since 2001 (3)] or by a selective sweep linked to the particular ticks and host reservoir in Camargue. The 5 species of ticks that we found positive for A. phagocytophilum have been described as potential vectors of A. ...
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We conducted a complete genome analysis of a West Nile virus detected in Culex pipiens mosquitoes during a severe outbreak of human West Nile disease in Greece 2010. The virus showed closest genetic relationship to the lineage 2 strain that emerged in Hungary in 2004; increased virulence may be associated with amino acid substitution H249P.
متن کاملWest Nile Virus Lineage 2 from Blood Donor, Greece
To the Editor: West Nile virus (WNV) is a mosquito-borne fl avivirus that primarily causes an asymptomatic or mild disease in humans; however, in <1% of infected persons, it causes neurologic disease. The virus has received increased attention since 2002 when it was established that WNV is transmissible by blood transfusion and organ transplantation (1). A major WNV outbreak occurred in 2010 in...
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ژورنال
عنوان ژورنال: Veterinary Pathology
سال: 2014
ISSN: 0300-9858,1544-2217
DOI: 10.1177/0300985813520246